Human genes create Down's syndrome mice

Nearly complete chromosome introduced to produce most successful disease model yet Scientists have introduced most of a human chromosome into mice to produce the most successful model yet of Down's syndrome. The researchers say their work—published in Science—could aid studies into Down's and other chromosomal diseases.

Previously, it has only been possible to place chromosome fragments into mouse cells, according to a BBC News report.

Led by Victor Tybulewicz at the National Institute for Medical Research and Elizabeth Fisher from the Institute of Neurology at University College London, the UK researchers have now added about 90% of the 250 genes on human chromosome 21 into mice.

They introduced the genes into mouse embryonic stem cells.

They then used the cells to create a strain of mice carrying the extra human chromosome.

The mice have problems with memory, brain function and heart formation similar to those of people with Down's syndrome.

Researchers can now work with the mouse model to better understand Down's, such as by removing genes to see which are responsible for particular aspects of the disease.

source: betterhumans