"Nanobombs" could blow up cancer

Carbon Nanotube

Researchers have created "nanobombs" that can produce nanoscale explosions to blow up cancer. Balaji Panchapakesan of the University of Delaware has reported on the nanobombs in both NanoBiotechnology and Oncology Issues. Panchapakesan says the nanobombs are in the early stages of development, but that the goal is to use them in medical applications. "Make no mistake, we are focused on eradicating cancer," he says.

According to a news release, the nanobombs grew out of work over the past two years with carbon nanotubes:

Originally, he said, the research team was looking at the use of the carbon nanotubes as drug delivery vehicles. Because they are smaller than the size of a single cell, the nanotubes can provide for the highly selective injection of drugs into individual cells.
As they undertook various experiments, however, the team made a startling discovery. "When you put the atoms in different shapes and forms, they take on different properties at the nanoscale," Panchapakesan said. "We were experimenting with the molecules and considering optical and thermal properties, and found we could trigger microscopic explosions of nanotubes in wide variety of conditions."

Explosions in air of loosely packed nanotubes have been seen before in an oxygen environment, creating ignition. However, the work reported by Panchapakesan uses the localized thermal energy imbalance to set off explosions that are intrinsic in nature.

Panchapakesan said the nanobombs are just that, tiny bombs on the nanoscale. "They work almost like cluster bombs," he said. "Once they are exposed to light and the resulting heat, they start exploding one after another."

The bombs are created through the bundling of carbon nanotubes. Nanotubes dissipate heat generated by the light into surrounding air. In bundles, they can't dissipate the heat as quickly and the result is "an explosion on the nanoscale," says Panchapakesan.


According to the news release, this could be exploited to destroy tumors:


When the UD researchers saw the explosions, they realized it might be possible to use the microscopic bombs to kill cancer cells. They recreated the explosions in solutions including water, phosphate and salt, which meant the nanobombs could be used in the human body. In fact the explosions were more dramatic in saline solutions, Panchapakesan said.

"The nanobomb is very selective, very localized and minimally invasive," Panchapakesan said. "It might cause what I would call nanopain, like a pin prick."

He believes the nanobomb holds great promise as a therapeutic agent for killing cancer cells, with particular emphasis on breast cancer cells, because its shockwave kills the cancerous cells as well as the biological pathways that carry instructions to generate additional cancerous cells and the small veins that nourish the diseased cells. Also, it can be spread over a wide area to create structural damage to the cancer cells that are close by.

The nanobombs could also offer advantages over other nanotech treatments as they are destroyed along with cancer cells. Macrophages then clear cell debris and exploded nanotubes, preventing nanoparticles from jamming up in the body.

source: betterhumans